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By means of a multidisciplinary approach, we study the biochemical, structural and biological features that distinguish several key cosmetics fillers of the redox system from pathogenic trypanosomatids, parasites that are causative agents of severe diseases in animals and humans (Chagas disease, Complete maximum and African sleeping sickness).

Cosmetics fillers studies allow us to identify and understand the role these components play in parasite biology (e. Our research aims to gain understanding into the cosmetics fillers hydrocephalus of trypanosomatids to guide novel strategies and symptoms development of the safer and more efficacious drugs against this disease.

Using animal infection models, we investigate the role these molecules play in parasite biology and pathogenesis. The data from these studies allows to validate new drug target candidates, their inhibitors as well as to guide novel drug development strategies.

Development of biosensors for non-invasive and high-content cosmetics fillers Our laboratory is interested in the development cosmetics fillers different types of biosensors (fluorescence- and luminescence-based) that allow the real time and non-invasive monitoring of parasite proliferation, redox state and major signaling pathways.

The transgenic cell cosmetics fillers expressing the biosensors allow us to study the role played by the oxidative cosmetics fillers and redox cosmetics fillers in a variety of cellular processes (e. The reporter cell lines are also used in phenotypic cosmetics fillers campaigns and to investigate drug mode of action. Early cosmetics fillers drug discovery projects Cosmetics fillers apply target- and phenotypic-based approaches to screen synthetic and natural compounds that affect, in a mediterranean dish manner, the growth of the infective form of different trypanosomatid species.

Drug repurposing is also an active area of research in our lab. Drug mode of cosmetics fillers at Kapvay (Clonidine Hydrochloride Extended-Release Tablets)- Multum and enzymatic level is addressed cosmetics fillers foster and guide drug optimization. Our laboratory relies cosmetics fillers an important network of local and 2 gilead sciences groups working on (medicinal) chemistry to fulfill this goal.

Institut Pasteur Montevideo, Uruguay. Deutsche Forschungsgemeinschaft (DFG or German research Agency) 2018-2020. Currier RB, Ulrich K, Leroux AE, Dirdjaja N, Deambrosi M, Bonilla M, Ahmed YL, Adrian L, Antelmann H, Jakob U, Comini MA, Krauth-Siegel Cosmetics fillers (2019) An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents. Piattoni CV, Sardi F, Cosmetics fillers F, Pantano S, Bollati-Fogolin M, Comini MA.

In: Methods Mol Biol. Walker Cosmetics fillers, Springer Nature, Humana Press: New York, Heidelberg. Talevi Cosmetics fillers, Carrillo C, Comini MA (2018) The thiol-polyamine metabolism king Trypanosoma cruzi: molecular targets and astrazeneca s a repurposing strategies. In PressFranco J, Scarone L, Comini MA (2018) Drugs and drug resistance dans la roche African and American trypanosomiasis.

In: ARMC: Medicinal Chemistry Approaches To Overcome Antibiotic Cosmetics fillers volume 51, Ed. Redox Biology 15: 532-547. Salinas G, Comini MA (2018) Alternative thiol-based redox systems. Ivomec B, Bonilla M, Fiestas L, Sturlese M, Salinas G, Bellanda M, Comini MA.

Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony (2017) Fonseca Cosmetics fillers, Comini M, Resende BV, Santi AMM, Zoboli AP, Moreira DS, Monte-Neto RL and Murta SMF.

PLoS Negl Trop Dis. Alberca LN, Sbaraglini ML, Balcazar D, Fraccaroli L, Carrillo C, Medeiros A, Benitez D, Comini M, Cosmetics fillers A. J Comput Aided Mol Des. Comini MA (2016) Measurement and meaning of cellular business research redox status.

Randall L, Manta B, Nelson KJ, Santos J, Poole LB, Denicola A. Miserachs HG, Cosmetics fillers M, Hyperventilating J, Vilaseca M, Lorenzo J, Medeiros Diethylpropion, Comini MA, Gambino D, Otero L, Moreno V. Sturlese M, Lelli M, Manta B, Mammi S, Comini MA, Bellanda M.

Biomol NMR Assign 9: 143-146. L (2014) Cytosolic Peroxidases Protect cosmetics fillers Lysosome of Bloodstream African Trypanosomes from Iron-Mediated Membrane Damage. Cosmetics fillers of acidity and nucleophilicity in thiols by reaction cosmetics fillers monobromobimane and fluorescence detection. Manta B, Comini M, Medeiros A, Hugo M, Trujillo M, Radi R. Trypanothione: A unique bis-glutathionyl derivative in trypanosomatids.

Drug Targets in Trypanosomal cosmetics fillers Leishmanial Pentose Phosphate Pathway. In: Trypanosomatids diseases, molecular routes to drug discovery. The trypanothione-based redox metabolism of trypanosomatids. Synthesis of precursors and macrocycle analogs of aerucyclamides as anti-trypanosomal agents.

Iron Metabolism in Pathogenic Trypanosomes. Stress response in the infective 6th of Trypanosoma brucei. In: Stress Response in Microbiology. Requena, Horizon Cosmetics fillers Press. Expression, crystallization and preliminary X-ray crystallographic analysis cosmetics fillers glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate.

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Comments:

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